Innovative immunotherapy
XENOTHERA is addressing unmet medical needs with proprietary Glyco-Humanized Antibodies:
Therapeutic domains:
TEAM
Odile Duvaux
Chief Executive Officer
M.D., Ph. D., formerly main partner in a consultant firm specialized in strategy DMJ Consultants
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Bernard Vanhove
Chief Operating Officer
Ph. D., immunilogist, formerly Research Director at CNRS and INSERM, co-founder and ex-COO of Effimune
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Didier Coquoz
Clinical & Regulatory Affairs
PhD in clinical pharmacology, Chief Development and Regulatory Officer for biotech/small pharmas
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Alexandre Lemoalle
Business Development
Former M&A VP for Sanofi, had many finance experiences in the pharmaceutical industry
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Elsa Lheriteau
Project Manager
Ph. D. in Gene Therapy, Molecular Biology and Vectorology, University of Nantes, France
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Carine Ciron
Research Engineer
Ph. D. in Gene Therapy, Molecular Biology and Vectorology, University of Nantes, France
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Sophie Despons
Administration & Finance
External Contractor
Scientific advisor
Jean-Paul Soulillou
Emeritus Professor of Medicine, worldwide renowned immunologist. 2016 winner of the Medawar Prize
MoreExternal Contractor
Scientific advisor
Emanuele Cozzi
Chairman of the Scientific Advisory Board
MD, Professor of Immunology at the University of Padua, former chairman of the International Xenotransplantation Association
MoreExternal Contractor
Scientific advisor
Jean-Marie Bach
D.M.V., Ph.D., Professor at Oniris, Veterinary school of Nantes
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Scientific advisor
Sophie Brouard
D.M.V., Ph.D., leads a team of 32 researchers at ITUN, specialist in immunology and transplantation
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Genetic Engineering
Cesare Galli
D.M.V., Ph.D., founder of the company Avantea (Cremona, Italy), worldwide renowned animal genetic engineer
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Development & Market Access
Marc Bouillet
M.D., former partner/CEO in several pharmaceutical companies and patient associations
MoreAn agile company with a fast-paced development
XENOTHERA is a clinical stage biotech at the top of innovation, which creates new therapeutic modes in numerous domains. Our patented technological platform is built on a double expertise of immunology and genetic engineering. It develops innovative approaches in immunotherapy by marketing Glyco-Humanized Polyclonal Antibodies (GH-pAb). Our antibodies are engineered to display high therapeutic properties. XENOTHERA’s platform ensures short-time development thanks to our mastery of the entire process, from animal genetics, choice of the immunogen, selection and purification of antibodies, and access to market authorization in accelerated timescale. Within less than 5 years, XENOTHERA has brought to clinic its first product LIS1, a novel induction treatment in Solid Organ Transplantation, addressing a $1Bn market. It has also established in vivo Proof-of-Concept in Immuno-Oncology and Multi-Drug Resistant infections.
Pipeline
Products in development
Latest News
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Related scientific papers
Next-generation Porcine Low Immunogenicity Anti-Lymphocyte Immunoglobulins shows selective depletion of T lymphocytes versus Treg and Breg
Rousse et al, ESOT 2019, Copenhagen, Denmark
LINKAnti-Neu5Gc responses in kidney allograft recipients after treatment with Rabbit Anti-Thymocyte Globulins.
Rousse et al, ESOT 2019, Copenhaguen, Denmark
LINKNext-generation Porcine Low Immunogenicity Anti-Lymphocyte immunoglobulins efficiently delay skin graft rejection in non-human primate
Ciron et al, ESOT 2019, Copenhagen, Denmark
LINKQuantitative and qualitative changes in anti-Neu5Gc antibody response following rabbit anti-thymocyte IgG induction in kidney allograft recipients
Rousse et al, Eur J Clin Invest. 2019. Apr;49 (4)
LINKAnti-Gal and anti-Neu5GC responses in non-immunosuppressed patients following treatment with Anti-Thymocyte Globulin
Salama et al, 2017
LINKNeu5Gc and α1-3 GAL Xenoantigen Knockout Does Not Affect Glycemia Homeostasis and Insulin Secretion in Pigs
Salama et al, 2017
LINKAnti-EBOV GP IgGs Lacking α1-3-Galactose and Neu5Gc Prolong Survival and Decrease Blood Viral Load in EBOV-Infected Guinea Pigs
Reynard et al, PLoS One. 2016
LINKRabbit antithymocyte globulin-induced serum sickness disease and human kidney graft survival
Couvrat-Desvergnes et al, J Clin Invest. 2015
LINKPotential deleterious role of anti-Neu5Gc antibodies in xenotransplantation.
Salama et al, Xenotransplantation. 2015
LINKLong-term IgG response to porcine Neu5Gc-antigens without transmission of PERV in burn patients treated with porcine skin xenografts
Scobie et al, J Immunol. 2013
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Xenothera is a start-up in biotechnology, specialized in immunology, infectious diseases and oncology
Investors already trusted us in 2014, 2016 and 2018 by funding the company for 6M€. XENOTHERA is currently preparing its series B fundraising in order to finance LIS1 pivotal trial and to bring two other products to clinic (XAB05 in MDR infections, XON03 in oncology ). Our products will offer a substantial patient benefit and aim to solve major public health issues.